Silylating Reagents

Silylation is the most widely used derivatization technique. Functional groups that present a problem with gas chromatogaphy detection - hydroxyl, carboxylic acid, amine, thiol, phosphate - can be derivatized by silylation reagents. Silylation involves replacement of the acidic hydrogen with an alkylsilyl group, for example, -SiMe₃.
Silylation derivatives are generally less polar, more volatile and thermally more stable. The choice of a silylating reagent is based on its reactivity and selectivity towards the compound, the intended application, the stability of the derivative, and the abundance/nature of reaction byproducts.

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Product #	Description
43340	1,1,3,3-Tetramethyl-1,3-diphenyldisilazane purum, ≥97.0% (GC)
41663	1,3-Dimethyl-1,1,3,3-tetraphenyldisilazane purum, ≥98.0% (NT)
92718	1-(Trimethylsilyl)imidazole - Pyridine mixture for GC, 1:4 (v/v)
92751	1-(Trimethylsilyl)imidazole purum, ≥98.0% (T)
19920	1-(tert-Butyldimethylsilyl)imidazole purum, ≥95.0% (GC)
details	BSA Derivatization Grade
15256	BSA+TMCS for GC, with 5% trimethylchlorosilane
33027	BSTFA, Derivatization Grade pkg of 25 mL
14755	Bis(dimethylamino)dimethylsilane purum, ≥95.0% (GC)
92337	Bromotrimethylsilane purum, ≥97.0% (AT)
76750	Chlorodimethyl(pentafluorophenyl)silane purum, ≥95.0% (GC)
90383	Chlorotriethylsilane purum, ≥97.0% (GC)
92090	Chlorotriisopropylsilane purum, ≥95.0% (GC)
33014	Chlorotrimethylsilane pkg of 100 mL
92360	Chlorotrimethylsilane puriss., ≥99.0% (GC)
33009	Dichlorodimethylsilane pkg of 100 mL
33046	HMDS+TMCS 3:1, pkg of 20 × 1 mL
52619	Hexamethyldisilazane puriss. p.a., for GC, ≥99.0% (GC)
52630	Hexamethyldisiloxane puriss., ≥98.5% (GC)
15248	N,N′-Bis(trimethylsilyl)urea purum, ≥98.0% (N)
15235	N,N-Bis(trimethylsilyl)methylamine purum, ≥97.0% (GC)
41720	N,N-Dimethyltrimethylsilylamine purum, ≥95.0% (GC)
15269	N,O-Bis(trimethylsilyl)acetamide purum p.a., for GC, ≥97.0% (GC)
15241	N,O-Bis(trimethylsilyl)acetamide purum, ≥95.0% (GC)
15236	N,O-Bis(trimethylsilyl)carbamate purum, ≥98.0% (T)
15238	N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane for GC, with 1% trimethylchlorosilane
15209	N,O-Bis(trimethylsilyl)trifluoroacetamide with trimethylchlorosilane for GC, with 10% Trimethylchlorosilane
15222	N,O-Bis(trimethylsilyl)trifluoroacetamide puriss. p.a., for GC, ≥99.0% (GC)
15243	N,O-Bis(trimethylsilyl)trifluoroacetamide purum, ≥98.0% (GC)
69479	N-Methyl-N-(trimethylsilyl)trifluoroacetamide puriss. p.a., for GC, ≥98.5% (GC)
90228	N-Methyl-N-(trimethylsilyl)trifluoroacetamide puriss. p.a., for GC, ≥98.5% (GC)
69478	N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane for GC
69480	N-Methyl-N-trimethylsilylacetamide purum, ≥97.0% (GC)
69484	N-Methyl-N-trimethylsilylheptafluorobutyramide technical, ≥90% (GC)
12124	N-Methyl-N-trimethylsilyltrifluoroacetamide activated III for GC, activated with imidazole
04438	N-Methyl-N-trimethylsilyltrifluoroacetamide activated III for GC, activated with imidazole
18369	N-Methyl-N-trimethylsilyltrifluoroacetamide activated II for GC, activated with MSTFA II
44156	N-Methyl-N-trimethylsilyltrifluoroacetamide activated II for GC, activated with trimethylsily-ethanethiol
12245	N-Methyl-N-trimethylsilyltrifluoroacetamide activated I for GC, activated with ethanethiol and ammonium iodide
50992	N-Methyl-N-trimethylsilyltrifluoroacetamide activated I for GC, activated with ethanethiol and ammonium iodide
19918	N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane purum
19915	N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide purum, ≥97.0% (GC)
85431	Silylating mixture Fluka I according to Sweeley for GC, ready to use solution in pyridine (10 vol parts)
85434	Silylating mixture Fluka I according to Sweeley for GC, ready to use solution in pyridine (10 vol parts), ampule
85432	Silylating mixture Fluka II according to Horning for GC
85435	Silylating mixture Fluka II according to Horning for GC, ampule
85433	Silylating mixture Fluka III for GC
85436	Silylating mixture Fluka III for GC, ampule
505846	Silylation Sampler Kit
33068-U	TMSI, Derivatization Grade pkg of 25 mL

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