Astec Products for Gas Chromatography (GC) & HPLC

In addition to the products below, we offer Chiral Analytical Services, including chiral screening, method development, and small-scale purification.

Chiral Gas Chromatography Columns

CHIRALDEX™ Capillary GC Columns

Chiral HPLC Columns

CHIROBIOTIC™ Chiral HPLC Columns

CHIROBIOTIC phases, based on covalently bonded macrocyclic glycoproteins to high purity silica gel, offer stability while retaining essential components for chiral recognition. Useful for LC-MS chiral applications and when reversed-phase solvents (methanol/water, acetonitrile/water) are preferred over normal phase solvents.

CYCLOBOND™ Chiral HPLC Columns

These bonded cyclodextrin stationary phases have the ability to form inclusion complexes, and allow for chemical separations by selectively including a wide variety of organic molecules from solution into the cyclodextrin cavity. CYCLOBOND I columns are ß-cyclodextrin bonded and CYCLOBOND II are ?-cyclodextrin bonded.

Copper Ligand Exchange Chiral HPLC Columns

Using the copper ligand concept, this phase resolves hydroxy acids like lactic, malic, tartaric and mandelic acids. The CLC phase can also resolve amino acids, other amines, and bi-functional racemates like amino alcohols by the same mechanism. In theory, any analyte that can complete the coordination with the copper ion can be resolved.

Protein Based Chiral HPLC Columns

Chiral-AGP phase offers a1-acid glycoprotein as chiral selector, Chiral-CBH phase offers cellobiohydrolase as chiral selector, and Chiral-HSA phase offers human serum albumin as chiral selector - immobilized on porous 5 µ spherical silica particles, and typically used in reversed-phase mode.

Polycyclic Amine Polymer Chiral HPLC Columns (P-CAP, P-CAP-DP)

These chiral phases offer a new bonding technology, primarily used in normal phase, for the separation of racemic compounds. Structural conformation and hydrogen bonding interactions are the driving mechanisms. Separations, including preparative, have been run in a variety of solvents including pure acetone, heptane/ethanol, dichloromethane/methanol and ethyl acetate.